DAWA TATU (Aspirin, Paracetamol and Caffeine)

DAWA TATU is a combination medicine, containing; Paracetamol, Aspirin and Caffeine. DAWA TATU tablets is indicated for the treatment of mild to moderate pain including headache, migraine, neuralgia, toothache, sore throat, period pains, symptomatic relief of sprains, strains, rheumatic pain, sciatica, lumbago, fibrositis, muscular aches and pains, joint swelling and stiffness, influenza, feverishness and feverish colds.

Paracetamol

Paracetamol, also known as acetaminophen, is a medication used to treat mild to moderate pain and reduce fever. It is available over-the-counter (OTC) and in prescription-strength formulations, and is used to relieve a variety of conditions, including headaches, menstrual cramps, toothaches, and arthritis pain.

Paracetamol works by blocking the production of prostaglandins, which are chemicals that promote inflammation and cause pain and fever. The medication is generally considered safe and well-tolerated when taken as directed, although it can cause liver damage if taken in excessive amounts.

Aspirin

Aspirin, also known as acetylsalicylic acid (ASA), is a medication commonly used to relieve mild to moderate pain, reduce fever, and prevent blood clots. It belongs to the class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs).

Aspirin works by blocking the production of prostaglandins, which are chemicals that promote inflammation, pain, and fever. It also reduces the ability of platelets in the blood to stick together and form clots, which can help prevent heart attacks and strokes.

In addition to its pain-relieving and blood-thinning effects, aspirin has been shown to have other potential health benefits, including reducing the risk of certain types of cancer and improving cognitive function in older adults.

However, aspirin can have side effects, including stomach upset, bleeding, and allergic reactions.

Caffeine

Caffeine is a natural stimulant that is commonly found in coffee, tea, energy drinks, and certain soft drinks. It is also available in the form of supplements and added to some over-the-counter medications.

Caffeine works by blocking the action of adenosine, a neurotransmitter that promotes sleep and suppresses arousal. This leads to increased levels of other neurotransmitters such as dopamine and norepinephrine, which can improve mood, attention, and alertness.

In addition to its stimulant effects, caffeine has been associated with several potential health benefits, such as improved athletic performance, reduced risk of certain diseases such as type 2 diabetes, and protection against cognitive decline.

However, caffeine can also have side effects, including restlessness, jitteriness, insomnia, increased heart rate, and high blood pressure. It is important to use caffeine in moderation and to avoid consuming excessive amounts. The optimal amount of caffeine varies among individuals, and it is recommended to consult with a healthcare professional to determine what amount is appropriate for you.

Posology and method of administration

Adults, the elderly and young person aged 16 and over, 2 tablets every 4 hours to a maximum of 8 tablets in 24 hours. Do not exceed 8 tablets a day. Do not give to children under 12 years, unless specifically indicated (for e.g. Kawasaki’s disease)

Contraindications

Hypersensitivity to the active ingredients or any of the excipients (Pre-gelatinised starch,, purified water, microcrystalline cellulose, crosspovidone, maize starch, colloidal anhydrous silica and stearic acid)
Peptic ulceration and those with a history of peptic ulceration
Hemophilia
Concurrent anti-coagulant therapy
Children under 12 years and when breast feeding because of possible risk of Reyes syndrome

Special warnings and precautions for use

Caution should be exercised in patients with asthma, allergic disease, impairment of hepatic or renal function (avoid if severe) and dehydration. The hazards of overdose are greater in those with non-cirrhotic liver disease

Do not take if you have a stomach ulcer
Do not take more medicine than the label tells you to. If you do not get better, talk to your doctor.
Do not take anything else containing paracetamol when taking this medicine.

Talk to your doctor at once if you take too much of this medicine, even if you feel well. This is because too much paracetamol can cause delayed, serious liver damage.

There is a possible association between aspirin and Reye’s syndrome when given to children. Reye’s syndrome is a very rare disease, which affects the brain and liver and can be fatal. For this reason aspirin should not be given to children under 12 years unless specifically indicated (Kawasaki’s disease)

Patients should be advised that paracetamol may cause severe skin reactions. If a skin reaction such as skin reddening, blisters, or rash occurs, they should stop use and seek medical assistance right away.

Pregnancy and lactation

Pregnancy

There are no adequate data available from the use of tablets in pregnant women. Animal studies have not been performed with Aspirin, paracetamol and caffeine in combination.

Aspirin: due to the presence of Aspirin, its use is contraindicated in the 3^rd trimester of pregnancy and caution should be exercised when used in the first 2 terms of pregnancy

Paracetamol: epidermiological studies indicate that under normal therapeutically conditions paracetamol can be used during pregnancy. Nevertheless, it should be used only after a careful benefit risk assessment has been done.

Caffeine: pregnant women are advised to limit their intake of caffeine to aminimum as the available data on the effect of caffeine on the human fetus suggests a potential risk.

Breast-feeding

Aspirin appears in breast milk, and regular high doses may affect neonatal clotting. Not recommended while breast feeding due to possible risk of Reye’s syndrome as well as neonatal bleeding due to hypoprothrombinaemia.

Paracetamol is excreted in breast milk but not in significant amount.

Caffeine appears in breast milk. Irritability and poor sleeping pattern in the infant have been reported.

Effects on ability to drive and use machines

No studies on the effects of the ability to drive and use machines have been performed. If you notice undesirable effects such as dizziness or drowsiness, you should not drive or use machines.

Undesirable effects

Side effects are mild and infrequent, but there is a high incidence of gastro-intestinal irritation with slight asymptomatic blood loss. Increased bleeding time. Aspirin may precipitate broncho spasm and induce asthma attacks or other hypersensitivity reactions, such as skin reactions (including angioedema and face oedema) in susceptible individuals.

Aspirin may induce gastro-intestinal haemorrhage, occasionally major. It may precipitate gout in susceptible individuals. Possible risk of Reye’s syndrome in children under 12 years.

Adverse effects of paracetamol are rare. Very rare cases of serious skin reactions have been reported. There have been reports of blood dyscrasias including thrombocytopenia purpura and agranulocytosis, but these were not necessarily causality related to paracetamol.

High doses of paracetamol can cause tremor and palpitations.

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DAWA TATU (Aspirin, Paracetamol and Caffeine)

DAWA TATU (Aspirin, Paracetamol and Caffeine)